http://www.ncbi.nlm.nih.gov/pubmed/16933260
Gene expression profile of idiopathic thrombocytopenic purpura (ITP).
特发性血小板减少性紫癜（ITP）的基因表达谱。
To search for novel mechanisms that contribute to the pathophysiology of idiopathic thrombocytopenic purpura (ITP), we determined the whole blood gene expression profile in five ITP patients and five control samples. Using DNA microarrays that contained 24,473 unique putative genes, we found 176 cDNAs that were strongly correlated with ITP. These included a cluster of interferon-regulated genes and TLR7, as well many less-well characterized genes which are candidates for further study. We believe this approach is likely to yield new insights into our understanding of the molecular pathophysiology of ITP.
寻找新的机制，有助于对特发性血小板减少性紫癜（ITP）的病理生理过程，测定全血基因表达谱对五例ITP患者和五个对照样本。利用DNA微阵列，包含24473个独特的基因，我们发现176个，ITP密切相关。这些包括一个集群干扰素调节基因的表达，也有许多不太好的特点，为进一步研究的候选基因。我们相信，这种方法可能会产生新的见解，我们对ITP的分子病理生理学理解。
Gene expression profile of idiopathic thrombocytopenic purpura (ITP).
特发性血小板减少性紫癜（ITP）的基因表达谱。
To search for novel mechanisms that contribute to the pathophysiology of idiopathic thrombocytopenic purpura (ITP), we determined the whole blood gene expression profile in five ITP patients and five control samples. Using DNA microarrays that contained 24,473 unique putative genes, we found 176 cDNAs that were strongly correlated with ITP. These included a cluster of interferon-regulated genes and TLR7, as well many less-well characterized genes which are candidates for further study. We believe this approach is likely to yield new insights into our understanding of the molecular pathophysiology of ITP.
寻找新的机制，有助于对特发性血小板减少性紫癜（ITP）的病理生理过程，测定全血基因表达谱对五例ITP患者和五个对照样本。利用DNA微阵列，包含24473个独特的基因，我们发现176个，ITP密切相关。这些包括一个集群干扰素调节基因的表达，也有许多不太好的特点，为进一步研究的候选基因。我们相信，这种方法可能会产生新的见解，我们对ITP的分子病理生理学理解。
