http://bnct.web.nthu.edu.tw/files/14-1155-12730,r11-1.php
新竹的国立清华大学～

清华大学水池式反应器BNCT（硼中子捕获治疗）设施开始治疗病人
清华大学核子工程与科学研究所　江祥辉 教授
本文同刊於清大原子科学院九月份电子报
BNCT（硼中子捕获治疗）是一种辐射标靶治疗方法，将含10B同位素亲癌细胞之药物慢慢滴注入人体内，等10B药物集中至癌肿瘤位置，当浓度足够高时，将病人移至由原子炉引出之中子束埠，利用中子束照射，当中子进入人体后，变成热中子，由於10B与热中子产生核反应的截面非常大，热中子随即与集中於肿瘤细胞内之10B发生核反应，反应生成的α和7Li两个粒子具有高能量，但其射程很短，约与细胞大小相当，因此只会把宿主癌细胞杀死，周围含硼浓度相对很小的正常细胞受影响的很少，几乎都能存活下来。BNCT主要用来治疗其他任何方法无法治疗的癌症，如恶性脑肿瘤、皮肤黑色素瘤以及复发性头颈癌。BNCT发展已有三、四十年历史，但全世界只有六、七个国家有BNCT设施和技术并用於人体治疗。目前世界上最活跃成功的BNCT设施当属日本和芬兰，累积已治疗了几千个病人。
BNCT（硼中子捕获治疗）除了用在惡性脑瘤（GBM）之治療外，近兩年來已广泛用於復发性头颈癌的治療，而后者之治療案例已可与前者分庭抗禮。2008年年初以來，清华BNCT研究团队与台北荣总癌症中心积极展开密切合作，目标即琐定利用清华BNCT设施从事復发性头颈癌人体治療。因为台湾头颈癌病人數目很多，而復发性头颈癌并无其他有效治療方法，BNCT由於其标靶特性且头颈癌通常深度较浅，正好是对於头颈癌很有潜力的治療方法。由日本与芬蘭近年许多成功治療案例可以支持我们所选定目标的正确性。BNCT对復发性头颈癌与惡性脑瘤（GBM）之治療，在药物和照射上似乎大同小異，虽然芬蘭团队只用BPA药物而日本团队除使用BPA外也有与BSH合并使用。BNCT向來主要用於惡性脑瘤（GBM）和皮肤黑色素瘤（Melanoma）之治療，近兩年來广泛用於治療復发性头颈癌，甚至也有論文报告在乳癌、早狀腺癌和肝癌治療上之应用。意大利团队最引以自豪的是利用BNCT从事肝癌体外治療：2001年首次对一位55岁病人从事肝癌体外BNCT治療，结果相当成功，病人存活了44个月。然而2003年第二度对一位39岁病人施以体外BNCT治療显然没有成效，病人只活了33天。
台北荣总癌症中心BNCT团队去年底开始向该院院内提出IRB申请利用清华水池式反应器B

台北荣总癌症中心BNCT团队去年底开始向该院院内提出IRB申请利用清华水池式反应器BNCT设施，执行BNCT复发性头颈癌人体试验，院内审查通过后，送卫生署审查，今年年中获卫生署审查通过。另一方面，清华水池式反应器BNCT设施亦获原子能委员会安全审查通过。经由紧锣密鼓的准备工作，一系列的设施操作流程测试、病人治疗流程测试以及治疗前病人定位设定，终於在8月11日和8月13日分别执行了国内第一位和第二位复发性头颈癌病人BNCT治疗，治疗过程顺利成功，病人感觉及病徵呈现均良好，为我国18年来BNCT的研究发展立下一道光明蓬勃的里程碑。

http://bnct.web.nthu.edu.tw/bin/home.php?Lang=zh-tw

16th International Congress on Neutron Capture Therapy
http://icnct16.org/
June 14-19, 2014 Helsinki, Finland
Dear colleagues,
The 16th International Congress on Neutron Capture Therapy (NCT) will take place for the first time in Fenno-Scandinavia, in Helsinki, Finland from Saturday June 14 through Thursday June 19, the week of midsummer.
The conference will offer the opportunity to present the latest clinical results in the treatment of cancer using Boron Neutron Capture Therapy (BNCT) and to learn of the latest techniques and clinical applications of the leaders in the various disciplines pertinent to BNCT. Key topical areas of the scientific program will include the development of hospital-deployable accelerator-based neutron sources and next-generation boron targeting agents for BNCT, as well as highlights of the latest basic biological, biophysical and clinical research. This meeting will be a perfect venue to meet and interact with multi-disciplinary experts in BNCT, to de

to develop new professional connections, and to contribute to ongoing advancements on the frontier of BNCT. During the conference, meetings of the governing bodies of the International Society for Neutron Capture Therapy (ISNCT), a General Assembly, and meetings of many specialized technical working groups will be conducted as well, offering additional opportunities to become involved in the many scientific aspects of this important field of medical research. specialties and Nordic design and culture in the attractive natural environment of the Finnish archipelago at midsummer, with its pleasant and seemingly endless days, will make this meeting even more special.

Thus it is my great pleasure to invite colleagues in all professions related to BNCT to the 16th ICNCT International Congress. The meeting will be a key milestone in the further development of BNCT as a single-session therapy in radiation oncology.
With best regards we cordially welcome you and your team in Helsinki.
Leena Kankaanranta
MD Oncologist
President of the International Society for Neutron Capture Therapy
President of the 16th ICNCT meeting